| Name(s) |
YELLAPRAGADA
SUBBAROW |
| Date of
Birth |
January 12, 1895 |
| Date of
Death |
August 09, 1948 |
|
Identity |
Great Indian Biochemist |
|
Other Events &
Developments |
- He is known world-wide for:
- Discovery of the role of
Phosphocreatine and Adenosine
Triphosphate (ATP) in muscular
activity
- Synthesis of Folic Acid
- Synthesis of Methotrexate
- Discovery of
Diethylcarbamazine
- After earning a diploma from the
Harvard Medical School he joined
Harvard as a junior faculty member.
- Jointly with Cyrus Fiske, he
developed a method for the
estimation of phosphorus in body
fluids and tissues.
- He discovered the role of
phosphocreatine and adenosine
triphosphate (ATP) in muscular
activity, which earned him an entry
into biochemistry textbooks in the
1930s.
- He obtained his Ph.D. degree
subsequently.
- Having been denied a regular
faculty position at Harvard, he
joined Lederle, where he developed a
method to synthesize folic acid,
Vitamin B9.
- Soon thereafter, he developed
the important anti-cancer drug
methotrexate - one of the very first
cancer chemotherapy agents and still
in widespread clinical use.
|
|
Awards and Accolades |
- A fungus was named
Subbaromyces splendens in
his honour by American Cyanamid.
- Writing in the April 1950 issue
of Argosy, Doron K. Antrim
observed, "You've
probably never heard of Dr.
Yellapragada Subbarow. Yet because
he lived you may be alive and are
well today. Because he lived you may
live longer."
|
|
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